Abstract:Focusing on the urban disease problems highlighted in recent years, previous studies have generally focused on the health benefits of blue-green space. At the same time, less attention has been paid to the thinking of space on the blocking mechanism of disease spread and spatial intervention, resulting in poor spatial control of urban disease problems. Therefore, by combining the cross-integrated development process of public health theory and landscape architecture practice, based on the principle of the “dose-response” relationship in public health, this study proposes a spatial mechanism analysis framework of “ spatial intervention-environmental factors - pathogenic factors - disease response”, forms a spatial intervention model that integrates the principles of public health and constructs a transformation path from public health theory research to landscape architecture design practice. By combining the typical urban disease problems in three different situations: atmospheric environment, water environment, and urban living environment, the application of the spatial mechanism framework is analyzed, the epidemic process of urban disease problems is traced from the spatial perspective, and the solution strategy is given. And further demonstrated the feasibility of applying the spatial mechanism framework in the actual case of malaria biological infectious diseases. The study emphasizes the importance of spatial intervention in the primary pandemic stage, aiming to promote the effective intervention of planning and design measures on urban diseases and to provide different perspectives for the current urban blue-green space planning and renewal to improve the comprehensive benefits of healthy cities in the post-epidemic era.